This guidance outlines the USAID approach to resilience, emphasizing the need to layer, integrate, and sequence humanitarian relief and development assistance efforts. It is designed for practitioners, partners, and stakeholders involved in humanitarian and development assistance, including those working in chronically vulnerable communities. The primary aim is to guide humanitarian assistance in seeking opportunities to not only save lives but also reduce vulnerability, laying the groundwork for longer-term development. Simultaneously, it encourages development assistance to engage in longer-time programming in chronically vulnerable communities and exhibit flexibility in higher-risk areas to build resilience and foster inclusive growth. It provides a framework for strategically aligning and coordinating relief and development efforts to address both immediate needs and long-term sustainability.